Long-term safety of a migraine medication in children and teens

Plain-English translation of NCT04743141 on ClinicalTrials.gov ↗ · Source last updated July 2026 · Translation generated July 2026 · How we translate trials

Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.

What is this trial?

This study is testing rimegepant, a medication designed to treat migraine attacks in children and teenagers. Researchers want to understand how safe this medication is and how well young people tolerate it when taking it over several months to treat their migraines. The study will follow about 600 children and teens to collect this important safety information.

While this medication has shown promise for treating migraines, doctors need to understand how safe it is specifically for younger patients over the long term. This trial will help ensure that the treatment is both effective and safe for children and teens who suffer from migraines.

Do you qualify?

You likely qualify if…

you are between 6 and 17 years old
you have been diagnosed with migraines (with or without aura) for at least 6 months
you experience 1 to 8 moderate or severe migraine attacks per month
you weigh more than 15 kg (or more than 25 kg if you're 12-17 in an EU country)
you can tell the difference between a migraine and other types of headaches
you had at least one migraine that needed treatment during a recent observation period

You likely don't qualify if…

you have cluster headaches or hemiplegic migraines
you have an untreated or uncontrolled psychiatric condition, or a history of psychosis or mania
you have a history of suicidal thoughts or self-harm
you currently use drugs of abuse or tested positive for them at screening
you have a history of substance abuse

What participation looks like

You would take the medication (available in tablet form) to treat your migraine attacks as they occur over several months. You'll attend multiple clinic visits where the research team will check on how you're doing, ask about any side effects, and make sure the treatment is working well for you. Blood samples may be taken to monitor your health and safety throughout the study.

AI-generated summary from trial data · Jul 10, 2026 · Not medical advice

Trial locations(124 sites)

United States

Perseverance Research Center, LLC, Scottsdale, Arizona

Physicians Research Group, Tempe, Arizona

Advanced Research Center, Inc., Anaheim, California

ProScience Research Group, Culver City, California

Neuro-Pain Research Center, Fresno, California