Plain-English translation of NCT04754672 on ClinicalTrials.gov ↗ ·
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether exercise — either aerobic fitness training, muscle-building workouts, or a combination of both — can help people with advanced colorectal cancer handle chemotherapy more safely. Researchers know that over 40% of patients need to reduce or delay their chemotherapy doses because of side effects, and this can make the treatment less effective. The study wants to see if staying physically active during treatment can reduce these problems and help patients live longer.
Studies have shown that patients with lower fitness levels and less muscle mass experience more severe chemotherapy side effects and don't do as well overall. This trial exists to find out whether exercise can truly prevent or reduce these toxicities, allowing patients to stay on their full treatment dose and improve their chances of survival.
You likely qualify if…
You likely don't qualify if…
You would be randomly assigned to one of two exercise groups. Both groups would participate in supervised exercise sessions twice per week — either 60 minutes of combined aerobic and muscle-building workouts, or 60 minutes of aerobic exercise combined with aerobic interval training. You would also be asked to do at least 30 minutes of moderate exercise at home once a week. The supervised sessions would be led by a physiotherapist, and your exercise intensity would be adjusted every 3–4 weeks as your chemotherapy progresses.
AI-generated summary from trial data · Aug 2, 2026 · Not medical advice
Netherlands