Recruiting

Mobile app to help adjust water pills for fluid buildup

Plain-English translation of NCT04759274 on ClinicalTrials.gov ↗ · Source last updated September 2025 · Translation generated June 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing a smartphone application called Diuretic Tuner that helps guide daily adjustments to your water pills (diuretics) based on your weight and blood pressure readings. The app works with your doctor's guidance to help you reach and maintain a healthy fluid balance if you have kidney disease and fluid buildup in your body.

Many patients with kidney disease struggle to manage their water pill doses on their own, often leading to either too much fluid buildup or dangerous drops in important minerals. This app aims to make it easier for you to safely adjust your medication at home with personalized guidance.

Do you qualify?

You likely qualify if…

you have significant protein in your urine (nephrotic range proteinuria) or advanced chronic kidney disease (stage 4 or 5)
you show visible signs of fluid buildup such as swelling in your legs, fluid in your belly, or fluid around your lungs
your current body weight is at least 5 pounds more than your target dry weight (the weight your doctor estimates you should be without excess fluid)
you weigh between 100 and 300 pounds
you own a working smartphone and are willing to measure your weight and blood pressure at home daily

You likely don't qualify if…

you have low potassium levels in your blood at the start of the study
you have severe low sodium levels in your blood
you have severely reduced kidney function with very high creatinine levels
you are expected to need dialysis within the next three months
you are unable to use a smartphone or have a condition like dementia or severe vision loss that would prevent you from using the app safely

What participation looks like

You will use the Diuretic Tuner app on your smartphone to track your daily weight and blood pressure, which you'll measure at home. The app will give you personalized guidance on how to adjust your water pill dose based on these measurements. The app will also keep a record of your fluid intake, blood pressure, weight, and whether you took your medications — all information your doctor can review. The study lasts three months and focuses on whether the app helps you safely reach and maintain your target weight.

AI-generated summary from trial data · Jun 15, 2026 · Not medical advice

Trial locations(1 site)

United States

University of Texas Southwestern, Dallas, Texas