Plain-English translation of NCT04759443 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This trial is testing a new way to diagnose small fiber neuropathy—a condition where the smallest nerves in your body gradually stop working, causing burning pain, dizziness, fatigue, and other disabling symptoms. Instead of using invasive procedures, researchers are developing a method that analyzes photographs of your skin to detect signs of nerve damage. The accuracy of this imaging approach will be compared against the current gold-standard test (skin biopsy) to see if it works.
Small fiber neuropathy affects millions of people worldwide, but diagnosing it is difficult and often requires invasive procedures available only in specialized centers. This trial exists to create a simpler, less invasive way to diagnose this condition so patients can get accurate diagnoses and start treatment sooner.
You likely qualify if…
You likely don't qualify if…
You will have photographs taken of your skin, likely on your leg. The research team will use special software to analyze these images and look for patterns related to nerve fiber loss. Your results will be compared to your previous skin biopsy results to determine if this imaging method is accurate. The study involves minimal discomfort and no medications.
AI-generated summary from trial data · Jun 1, 2026 · Not medical advice
United States
Enrollment target
~400 participants
Started
July 2021
Primary completion
February 2027
Age range
18 Years and older
Last updated on clinicaltrials.gov in February 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Peter Novak, MD
Brigham and Women's Hospital
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.