Plain-English translation of NCT04761991 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Coronary Artery Disease research guide →This research study is testing whether two advanced imaging techniques—a special CT scan and a heart MRI scan—can accurately detect blocked arteries in your heart. The study will compare these non-invasive imaging methods to a gold-standard invasive procedure that directly measures blood flow in your coronary arteries. Your participation will help doctors understand which imaging approach works best to diagnose heart disease without unnecessary invasive procedures.
Currently, CT scans are widely used to rule out serious heart blockages, but they sometimes show false alarms that lead to unnecessary invasive procedures. This trial exists to determine whether adding advanced imaging techniques can more accurately identify which blockages actually need treatment, so fewer patients undergo unnecessary invasive testing.
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You will undergo the imaging scans that your doctor has already recommended for your condition. About 167 participants will also receive an additional accelerated heart MRI scan. You will then have your planned heart catheterization procedure (which your doctor already recommended), and researchers will compare how well each imaging method predicted the results of that procedure. The study will help determine which imaging approach is most effective at identifying significant heart blockages.
AI-generated summary from trial data · Aug 6, 2026 · Not medical advice
United Kingdom
Sponsor
University of Leicester
Collaborators
HeartFlow, Inc., National Heart, Lung, and Blood Institute (NHLBI)
Enrollment target
~300 participants
Started
November 2020
Primary completion
November 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years and older
Last updated on clinicaltrials.gov in July 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Jayanth Arnold
University of Leicester
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.