Plain-English translation of NCT04762134 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing doxycycline, a common antibiotic, as a way to prevent sexually transmitted infections like syphilis, gonorrhea, and chlamydia. Participants will be randomly assigned to take the medication in one of two ways: either daily as a preventive measure, or as a single dose after a sexual encounter. The study will follow participants for 15 months to see which approach works best and is easiest to use.
Sexually transmitted infections are spreading rapidly among gay and bisexual men in Canada, and current prevention strategies are not working well enough. This medication offers a new tool that could help prevent serious infections and stop them from spreading to others.
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If you join, you will be randomly assigned to one of two groups: either taking the medication daily as a preventive, or taking a single dose after sexual encounters that carry risk. You will visit the clinic for check-ups over 15 months, answer questions about your sexual health and medication use, and complete regular testing for infections. The study team will also ask about any side effects and how easy or difficult it is for you to stick with the treatment plan.
AI-generated summary from trial data · Sep 24, 2026 · Not medical advice
Canada