Plain-English translation of NCT04767048 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether combining two surgical techniques — removing tissue from the base of the tongue (using either a robot or laser) along with tonsil removal — helps doctors better identify the source of cancer in patients with enlarged neck lymph nodes. Some patients will receive both procedures, while others will receive tonsil removal alone. The study wants to see if the additional tongue tissue removal improves doctors' ability to find where the cancer is coming from.
Sometimes patients have enlarged lymph nodes in the neck that contain cancer cells, but doctors cannot find where the original tumor started — even after extensive testing. This trial exists to see if removing tissue from the base of the tongue during surgery can help doctors discover these hidden primary tumors, which would allow for better treatment planning.
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You will undergo surgery where your tonsils are removed and, depending on which group you are randomly assigned to, tissue from the base of your tongue may also be removed using either robotic or laser technology. These procedures help doctors collect tissue samples to identify where your cancer originated. After surgery, you will have follow-up visits and imaging to monitor your recovery and determine the best next steps for your treatment plan.
AI-generated summary from trial data · Jun 30, 2026 · Not medical advice
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