Plain-English translation of NCT04781972 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
Researchers want to understand exactly how —a common ADHD medication—changes brain activity and brain chemistry in people with ADHD. This study uses advanced brain imaging to measure those changes after you take a single dose of the medication or a placebo, so scientists can better predict who will benefit from this treatment and develop improved medications in the future.
While this medication has been used for decades, doctors don't fully understand how it works in the brain or why it helps some people more than others. This research aims to identify biological markers that could predict treatment response and guide the development of better ADHD medications.
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You will visit the research center twice, about one week apart. At each visit, you'll take either the medication or a placebo pill, then complete thinking and memory tests while researchers scan your brain using two types of imaging machines (fMRI and MRS). Each visit will take a few hours. The study uses a crossover design, meaning you'll receive both the medication and placebo across your two visits so researchers can compare how your brain responds to each.
AI-generated summary from trial data · Jun 14, 2026 · Not medical advice
United States