Plain-English translation of NCT04788524 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Major Depressive Disorder research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers want to understand how stress and feeling in control (or out of control) affect the brains of teenage girls with depression. Using special brain imaging called fMRI, they'll take pictures of your brain while you complete some computer tasks, and ask you questions about your mood and stress levels. This will help scientists learn more about how depression develops in teens.
Depression in teenagers is common and serious, but we still don't fully understand why some teens develop it and others don't. This research aims to discover how stress and a sense of control change the brain in depression, which could eventually lead to better treatments.
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You would visit McLean Hospital four times over six months. At your first visit, you'll complete interviews and questionnaires about your mood and stress. At your second visit, you'll have a brain scan (fMRI) while completing computer tasks, and then answer surveys on your phone for the next week. You'll return three months and six months later for follow-up interviews, questionnaires, and another week of phone surveys. The whole study takes about six months.
AI-generated summary from trial data · Jul 5, 2026 · Not medical advice
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