Recruiting

Understanding BAP1 Gene Mutations and Cancer Risk in Families

Plain-English translation of NCT04792463 on ClinicalTrials.gov ↗ · Source last updated March 2026 · Translation generated June 2026 · How we translate trials

What is this trial?

This research study is trying to understand a gene called BAP1 that can increase the risk of certain cancers running in families. Researchers want to learn more about which cancers are connected to BAP1 mutations, so they can better help patients and families know what to watch for and how to stay healthy.

Scientists have discovered that some families carry a mutation in the BAP1 gene that raises their cancer risk, but they don't yet fully understand all the cancers it can cause or how often it happens. This study exists to fill those gaps so doctors can give families better guidance and care.

Do you qualify?

You likely qualify if…

you have been diagnosed with one of the cancers linked to BAP1 (such as eye melanoma, skin melanoma, kidney cancer, mesothelioma, or certain liver or brain cancers) and have at least two close relatives who also had these cancers
you have been diagnosed with at least two of the BAP1-related cancers yourself
you have had genetic testing that shows you carry a BAP1 gene mutation
you carry a BAP1 gene variant whose exact effect is still unknown, and you or your family have had one of the related cancers
you are a close relative of someone with a confirmed BAP1 mutation, even if you haven't had cancer yourself

You likely don't qualify if…

you do not speak English, as study materials are only available in English
you do not have a personal or family history related to the cancers this study focuses on

What participation looks like

Participation is observational, meaning you won't receive any new treatment—instead, researchers will gather information about your personal health history, your family's medical history, and genetic test results if you have them. This typically involves one or more visits where you share medical records and answer questions, and may include providing a blood or tissue sample for genetic testing if you haven't had one already.

AI-generated summary from trial data · Jun 7, 2026 · Not medical advice

Trial locations(1 site)

United States

The Ohio State University Wexner Medical Center, Columbus, Ohio