Plain-English translation of NCT04793867 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Cystic Fibrosis research guide →Researchers are testing whether special MRI scans can detect early lung damage in people with cystic fibrosis, especially in those whose standard breathing tests still look normal. The study uses two types of advanced imaging — -129 MRI and ultra-short echo time MRI — which are radiation-free alternatives to traditional CT scans. This imaging could help doctors predict which patients will develop serious lung problems in the future.
Many cystic fibrosis patients have lung damage that standard breathing tests don't catch until it's advanced. Finding a way to detect this damage earlier could help doctors start treatment sooner and slow down disease progression.
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If you join this study, you would come to the hospital once a year for about 1–2 hours. During each visit, you'll have two types of MRI lung scans (which are painless and use no radiation), perform a breathing test, and complete a lung clearance measurement. The study will continue for several years so researchers can track changes in your lungs over time. Visits will be coordinated with your regular clinic appointments when possible to minimize extra trips.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
United States
Sponsor
Children's Hospital Medical Center, Cincinnati
Enrollment target
~100 participants
Started
February 2021
Primary completion
March 2026
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
5 Years – 100 Years
Last updated on clinicaltrials.gov in February 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Penny A New, BBA
CCHMC
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.