Plain-English translation of NCT04794829 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This trial studied how the body builds and maintains immunity after receiving flu and COVID-19 vaccines. Researchers collected blood and nasal samples from NIH employees over the course of one year to understand how long-lasting protection develops after vaccination and how immune defenses work in different parts of the body.
Flu immunity fades quickly each year and flu viruses constantly change, making current vaccines less effective than desired. Similarly, doctors need to better understand how long-term protection develops after COVID-19 vaccination so they can develop improved vaccines in the future.
Participants visited the research team before receiving their vaccines to provide a baseline blood draw and nasal sample. They then received their flu and/or COVID-19 vaccines as planned. Over the following year, participants returned for additional blood draws and nasal samples at multiple time points to track how their immune system responded and changed over time. The study examined antibodies (immune proteins) in both the bloodstream and nasal passages.
AI-generated summary from trial data · Aug 5, 2026 · Not medical advice
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