Plain-English translation of NCT04798131 on ClinicalTrials.gov โ ยท Source last updated ยท Translation generated ยท How we translate trials
Read our Schizophrenia research guide โThis study doesn't follow the usual testing phases โ it may be an observational study or a different type of research.
This trial is testing a new approach called fMRI-based neurofeedback to help people with schizophrenia who experience persistent auditory hallucinations (hearing voices) that don't respond well to standard medications. During the trial, researchers will use real-time brain imaging to show you patterns of your brain activity and teach you techniques to shift your brain into a state where hallucinations are less likely to occur. The goal is to help you gain some control over these experiences through brain training.
Many people with schizophrenia continue to hear voices even when taking antipsychotic medications, which can be very distressing and disrupt daily life. This trial exists because researchers have discovered that they can now detect the brain patterns associated with hearing voices using advanced imaging, and they want to know whether teaching people to recognize and change those patterns could offer relief when medications alone are not enough.
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If you join this trial, you would be randomly assigned to either receive real brain training or a placebo (sham) training โ neither you nor the researchers would know which group you're in at first. You would participate in four sessions where you lie in an MRI brain scanner while watching visual feedback on a screen and following instructions designed to help shift your brain activity away from the hallucination state. The trial would track how much your hearing voices improves over the study period and for one month after treatment ends.
AI-generated summary from trial data ยท Jun 2, 2026 ยท Not medical advice
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