Plain-English translation of NCT04801589 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing whether , a sedation medication, is better than (the medication currently used most often) for children who need to be on breathing machines in the ICU. Researchers believe this medication may reduce confusion and delirium that can happen during critical illness, and may help protect children's brain function during and after their ICU stay.
Many children on breathing machines receive standard sedation that has been linked to longer hospital stays, increased confusion, and potential brain problems. Adult studies show that this medication may reduce these complications compared to standard sedation, but this benefit hasn't been proven yet in children.
If your child is enrolled, they will receive one of the two sedation medications through an IV while on the breathing machine in the ICU—the doctors will adjust the dose to keep your child at a comfortable level of sedation. Your child will be monitored continuously with heart monitors and other standard ICU equipment as usual. The medication will only be given while your child is in the ICU on the breathing machine, and the study team will track how your child recovers, including checking for confusion and any long-term effects on brain function.
AI-generated summary from trial data · Sep 17, 2026 · Not medical advice
United States