Plain-English translation of NCT04812314 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Obesity research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers know that exercise helps people with obesity and related health conditions, but they don't fully understand exactly how it works. This study will investigate how exercise training changes fat tissue at a microscopic level and whether these changes help the body handle weight loss and weight regain differently. You'll be randomly assigned to either exercise regularly or remain sedentary while your body goes through a controlled cycle of weight loss and weight regain.
Exercise is recommended as a first-line treatment for obesity and related metabolic diseases, yet scientists don't fully understand the biological mechanisms that make it work. This research could uncover how exercise changes fat tissue in ways that improve the body's ability to prevent insulin resistance and obesity-related diseases.
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Over approximately 8 to 10 months, you'll have multiple visits where researchers will perform metabolic tests (blood work, tissue samples, and body composition measurements). If assigned to the exercise group, you'll walk at a brisk pace for 45 minutes, 4 days per week, burning about 250 calories per session. If assigned to the control group, you'll continue your normal routine without planned exercise. Throughout the study, you'll go through a structured 10% weight loss program, then a weight regain phase where you'll eat a higher-calorie diet to regain half the weight you lost, with repeat testing at each stage. At the end, the study team will help you lose weight again if you wish.
AI-generated summary from trial data · Sep 5, 2026 · Not medical advice
United States