Plain-English translation of NCT04827498 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This research study is designed to help doctors better understand a condition where people experience chest pain and reduced blood flow to the heart, even though their main coronary arteries are not significantly blocked. Researchers will use special heart imaging procedures and tests to measure how well the heart's smaller blood vessels are working and how the heart muscle responds to certain medications. The goal is to see whether tailored treatment based on these detailed test results helps reduce chest pain and improve quality of life over time.
Many patients with chest pain are found to have normal or near-normal major heart arteries on standard tests, leaving them without clear answers about what's causing their symptoms. This study aims to identify the specific problems in the heart's smaller blood vessels and muscle function that lead to these symptoms, so doctors can offer more targeted and effective treatments.
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You will undergo specialized heart imaging procedures that measure blood flow and how your heart muscle responds to test medications injected into your coronary arteries. The visits include baseline testing and follow-up appointments at 30 days, 1 year, 2 years, and 5 years — conducted either at the clinic or by phone — during which you'll complete questionnaires about your chest pain symptoms. Your doctors will use the test results to create a personalized treatment plan, and the study team will track how well this approach helps reduce your symptoms over time.
AI-generated summary from trial data · Jul 13, 2026 · Not medical advice
Spain
Sponsor
Hospital San Carlos, Madrid
Collaborators
Fundacion Investigacion Interhospitalaria Cardiovascular
Enrollment target
~600 participants
Started
November 2017
Primary completion
December 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years and older
Last updated on clinicaltrials.gov in April 2021.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Hernan Mejia-Renteria, MD, PhD
Department of Cardiology, Hospital Clinico San Carlos
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.