Plain-English translation of NCT04838249 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This research is studying how cross-sex hormone therapy—testosterone for trans men and estrogen for trans women—affects the body beyond the expected changes. Researchers want to understand how these medications influence eating habits, weight, metabolism, and cardiovascular (heart and blood vessel) health. By comparing people starting the treatment with people not taking these hormones, the study aims to fill gaps in what we know about these medications' broader effects.
While cross-sex hormone therapy is an important part of gender-affirming care, we don't know enough about how it affects appetite, metabolism, weight, and heart health. Men and women naturally have different cardiovascular risks and eating patterns, and this treatment changes hormone levels significantly. This study exists to help doctors better understand and manage these changes in their patients.
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You would visit the research center multiple times for different tests that measure eating behavior, metabolism, weight, and heart health. Some visits include blood tests, questionnaires about appetite and eating habits, and possibly imaging scans (like an MRI). The exact schedule depends on which study components you participate in, but you would be compared with others undergoing the same measurements to help researchers understand how the medication affects your body over time.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
Germany