Receive surgery and heated chemotherapy treatment for abdominal cancer

What is this trial?

This trial is testing a treatment called hyperthermic intraperitoneal chemotherapy (HIPEC) — a heated chemotherapy delivered directly into the abdomen during surgery — for people with certain cancers that have spread across the abdominal lining. Before your surgery, doctors will test your tumor cells in the lab with different chemotherapy drugs to see which one works best for you. This personalized approach could help your doctors choose the most effective medication for your specific cancer.

Currently, doctors choose chemotherapy drugs based mainly on the type of cancer you have and their own experience, rather than on what might work best for your individual tumor. This trial aims to prove that testing your tumor cells beforehand can predict which medication will be most effective, potentially improving your treatment outcomes.

Do you qualify?

You likely qualify if…

you have been diagnosed with cancer that has spread to the abdominal lining (from ovarian, colorectal, appendiceal, or mesothelioma cancers)
you are at least 18 years old
your doctors believe you are healthy enough to undergo surgery to remove the cancer
you do not have cancer that has spread outside your abdomen to other parts of your body
your blood counts and organ function (liver and kidney) are adequate based on recent lab tests

You likely don't qualify if…

you have received chemotherapy in your abdomen or other cancer treatment within the past 4 weeks
you have had major surgery within the past 12 weeks
you are allergic to platinum-containing chemotherapy drugs
you are pregnant, breastfeeding, or unwilling to use birth control during treatment and for 6 months after

What participation looks like

If you enroll, you will have surgery to remove as much cancer as possible from your abdomen. Before and during surgery, doctors will collect small samples of your tumor. They will test these samples in the lab using different heated chemotherapy drugs to see which one kills your cancer cells most effectively. Based on the results, you will receive one of several chemotherapy medications heated and delivered directly into your abdomen during the surgery. You will also need to participate in a related tissue collection study to help researchers understand how the treatment works.

AI-generated summary from trial data · Jul 17, 2026 · Not medical advice

Testing personalized heat-based chemotherapy for abdominal cancers

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)