Plain-English translation of NCT04849806 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our COPD research guide →Researchers are trying to understand why people with chronic obstructive pulmonary disease (COPD) often have overactive nerves that control heart rate and blood pressure. This study will measure nerve activity in detail and compare it between people with COPD and healthy volunteers to identify what factors make the nerves overactive.
Doctors know that nerve overactivity happens in people with lung disease, but they don't fully understand why or what causes it. Understanding these patterns could help improve treatment for COPD patients and prevent related heart problems.
You likely qualify if…
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If you qualify, you will have a single study visit at the hospital where doctors will measure your nerve activity using specialized equipment, perform heart ultrasound, test your lung and breathing muscle function, and check your blood oxygen and carbon dioxide levels. You will also be screened for sleep apnea and have blood tests to check for inflammation. The visit will involve several different measurements and tests but no medications or invasive procedures.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
Germany
Sponsor
RWTH Aachen University
Collaborators
DFG - Deutsche Forschungs Gemeinschaft (German Research Foundation)
Enrollment target
~135 participants
Started
May 2022
Primary completion
December 2028
Age range
18 Years and older
Last updated on clinicaltrials.gov in January 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Michael Dreher, Professor
RWTH Aachen University
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.