Plain-English translation of NCT04854317 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Obesity research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing three different endoscopic procedures that reshape your stomach to help you lose weight. All three procedures work by making your stomach smaller or changing how it functions, without requiring traditional surgery. The study will help doctors understand which approach works best for different patients.
Obesity affects millions of people worldwide and can lead to serious health problems like heart disease, diabetes, and cancer. While traditional weight-loss surgery works well, it carries risks and requires a hospital stay. This trial exists to determine whether these newer, less invasive endoscopic procedures are effective and safe alternatives for people who haven't succeeded with diet alone.
You likely qualify if…
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If you enroll, you will be randomly assigned to receive one of three endoscopic procedures, all performed through your mouth without surgical cuts. The procedure is minimally invasive and typically involves a short hospital stay. After the procedure, you'll have follow-up visits to monitor your weight loss, how you're feeling, and how well the procedure is working for you. Success will depend partly on the procedure itself, but also on your willingness to make lasting changes to your eating habits and physical activity.
AI-generated summary from trial data · Jun 22, 2026 · Not medical advice
Italy
Sponsor
Mater Olbia Hospital
Enrollment target
~189 participants
Started
June 2020
Primary completion
February 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years – 70 Years
Last updated on clinicaltrials.gov in February 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Salvatore F. Vadalà di Prampero, MD, PhD
Gastroenterology and GI Endoscopy
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.