Plain-English translation of NCT04864080 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers want to understand how chronic pain and depression affect your ability to think and focus. This study uses brain imaging (MRI), brain stimulation (TMS), and brain wave recording (EEG) to look for shared patterns in how these two conditions change brain function. The goal is to develop better ways to diagnose and treat both conditions.
Many people with chronic pain or depression struggle with thinking problems like trouble concentrating. Researchers believe these two conditions may share similar brain changes, but we don't have good ways to measure this yet. This study could help doctors develop better tools to understand and treat both conditions.
You likely qualify if…
You likely don't qualify if…
If you are a healthy volunteer, you will complete online surveys and thinking tasks from home. If you have chronic pain or depression, you will visit the clinic for brain imaging (MRI scan), receive a form of brain stimulation (TMS), have your brain waves recorded while doing thinking tasks (EEG), and complete online surveys. The study involves 45 total participants and researchers will compare brain patterns across all three groups to find common markers.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
United States
Enrollment target
~45 participants
Started
April 2022
Primary completion
March 2027
Age range
18 Years and older
Last updated on clinicaltrials.gov in March 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
David Darrow
University of Minnesota
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.