Plain-English translation of NCT04873011 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Obesity research guide →Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
Researchers are testing , a bitter compound, to see if it can help reduce hunger and how much people eat. The study involves giving the medication through a feeding tube directly into the stomach and measuring how it affects appetite, food intake, and hormone levels in the blood. This is an early-stage study to understand whether this approach might one day help with weight management.
Being overweight increases health risks, and current weight-loss treatments don't work well for everyone. Researchers think bitter-tasting compounds in the stomach might trigger natural signals that make people feel fuller and eat less, offering a new way to help with weight management.
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You will visit the research center and receive either the bitter medication or a placebo (salt water) through a thin feeding tube placed in your stomach. Blood samples will be taken at several time points to measure hormone and blood sugar levels, and you will rate your hunger and fullness feelings using simple rating scales. The study uses a crossover design, meaning you may participate in two similar visits so researchers can compare how your body responds to the medication versus placebo.
AI-generated summary from trial data · Jun 20, 2026 · Not medical advice
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