Plain-English translation of NCT04873102 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether danazol, an oral medication taken daily, can help restore healthy blood cell counts in people with cirrhosis. Many patients with cirrhosis develop problems with low white blood cells, platelets, or red blood cells—a condition that can increase infection risk, bleeding risk, and other complications. This study will see if the medication can safely improve these blood cell counts over 24 months.
People with cirrhosis often develop dangerously low blood cell counts due to how the disease affects the bone marrow and spleen, but current treatments don't work well for everyone. Researchers believe this medication might work by helping the body maintain healthier blood cell production, especially in patients who have genetic changes affecting how cells protect themselves.
You likely qualify if…
You likely don't qualify if…
If you qualify, you will take a daily oral medication for 24 months while the research team monitors your blood cell counts and overall health through regular clinic visits and blood tests. The study is small (enrolling only 10 people at one center in Los Angeles) and will track whether the medication safely improves your blood counts and how well you tolerate it over this 2-year period.
AI-generated summary from trial data · Jun 27, 2026 · Not medical advice
United States
Phase
Testing effectiveness
Sponsor
University of Southern California
Enrollment target
~10 participants
Started
August 2024
Primary completion
August 2027
Age range
18 Years and older
Last updated on clinicaltrials.gov in July 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Ibrahim Syed, MBBS
Keck Hospital of USC
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.