Plain-English translation of NCT04891016 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This study is testing whether combining chemotherapy (called FLOT) with an immune-boosting medication called toripalimab works better for treating locally advanced stomach cancer before surgery. Patients receive three cycles of both treatments together, then have surgery to remove the tumor. After surgery, additional treatment is given based on how well the tumor responded.
Stomach cancer that has grown into surrounding tissue or lymph nodes is serious and difficult to treat. This trial is exploring whether adding an immune-boosting medication to standard chemotherapy can help destroy more cancer cells before surgery, potentially improving survival and outcomes.
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You would receive chemotherapy on Day 1 and the immune-boosting medication on Day 3, with this cycle repeating every 3 weeks for a total of 3 cycles (about 9 weeks). Then you would have surgery to remove the tumor. After surgery, based on how well your cancer responded, you would receive either 2 or 4 additional cycles of treatment. Throughout the trial, you would have regular blood tests and imaging scans to monitor your health and cancer response.
AI-generated summary from trial data · Jun 27, 2026 · Not medical advice
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