Plain-English translation of NCT04895709 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.
This is one of the first times this treatment has been tested in people.
This is an early-stage study testing a brand-new cancer medication called in people with advanced solid tumors (cancers that have spread). Researchers want to find the safest dose and understand how well this medication works, both when given alone and when combined with other established cancer drugs like nivolumab or . This is the first time this medication is being tested in humans.
Many people with advanced cancers stop responding to current treatments or cannot tolerate them. This medication targets a new pathway in cancer cells, and researchers hope it will offer another option for patients whose cancers are no longer controlled by standard therapies.
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If you enroll, you will receive the medication by mouth or infusion (depending on which group you join), possibly combined with other cancer drugs. You'll visit the clinic regularly for blood tests, scans, and check-ups to monitor how the medication is working and any side effects. The study includes multiple phases: first, doctors will carefully escalate the dose to find the safest level, then expand testing in larger groups of patients with similar cancer types. You will also need to provide tumor biopsies (small tissue samples) before and during treatment to help researchers understand how the medication affects your cancer cells.
AI-generated summary from trial data · Jul 3, 2026 · Not medical advice
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