Plain-English translation of NCT04898790 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Leukemia research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study is testing whether a physical activity program called CHAMPS-II can help improve thinking skills, memory, and overall quality of life in older adults who have received a stem cell transplant for blood cancers. Stem cell transplants involve intense chemotherapy and can affect how the brain works, especially in older patients. Researchers believe that regular physical activity might help protect and restore thinking abilities that treatment may have harmed.
Stem cell transplants can cause problems with memory and thinking skills that get in the way of returning to normal life and make patients feel worse overall. While exercise is known to help thinking skills in older adults and other cancer survivors, no one has tested whether this approach works specifically for people who have had stem cell transplants.
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The study has multiple parts. First, some participants will give feedback on the program materials through interviews. Then, participants will either start the exercise program before their transplant or after recovery (Day 180 post-transplant), depending on which group they are randomly assigned to. You would work with the program to gradually increase physical activity suited to your ability, while researchers measure your thinking skills, fitness, and quality of life at different time points. Some participants may also have blood tests, saliva samples, or brain imaging done to understand how exercise affects the body.
AI-generated summary from trial data · Jun 6, 2026 · Not medical advice
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