Testing a new cancer treatment for advanced solid tumors

This trial is testing a new medication called givastomig (TJ033721) to see if it can help treat advanced cancers that have spread to other parts of the body or are no longer responding to standard treatments. Researchers are first testing different doses of the medication alone to find the safest and most effective level. Later phases will test whether combining this medication with other cancer drugs or immunotherapy treatments works better.

Currently, many patients with advanced cancers like gastric, pancreatic, and biliary tract cancers have limited treatment options once standard therapies stop working. This medication targets a specific protein found on certain cancer cells, offering a potentially new way to fight these difficult-to-treat cancers.