Plain-English translation of NCT04903223 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
Researchers want to understand how rosuvastatin works in young people with high cholesterol, especially when fat builds up in the liver. The study will give some participants this medication and measure how their body handles it using blood tests and MRI imaging. This helps doctors figure out the best way to treat high cholesterol in young patients.
High cholesterol in children can lead to serious heart problems later in life, but we don't fully understand how this medication works in young people—especially those who may have extra fat in their liver. This trial will help doctors personalize cholesterol treatment for kids and teens.
You likely qualify if…
You likely don't qualify if…
You'll take rosuvastatin, a cholesterol medication, while the research team tracks how your body responds. You'll have blood tests to measure cholesterol levels and a substance called mevalonate, and you'll also get an MRI scan to see how much fat is in your liver. The study involves multiple visits to the hospital, and you'll need to come fasting (without eating beforehand) to some of them.
AI-generated summary from trial data · Jul 1, 2026 · Not medical advice
United States
Phase
Safety & dosing
Sponsor
Children's Mercy Hospital Kansas City
Enrollment target
~50 participants
Started
April 2021
Primary completion
October 2026
Age range
8 Years – 21 Years
Last updated on clinicaltrials.gov in June 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Jonathan Wagner, DO
Children's Mercy Hospital Kansas City
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.