Plain-English translation of NCT04908319 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers at Baylor College of Medicine are studying liver damage in people with urea cycle disorders — rare genetic conditions that affect how the body processes nitrogen. By reviewing liver biopsy and transplant samples from patients who have already had these procedures, the research team hopes to understand why some people with these disorders develop serious liver problems while others do not.
People with urea cycle disorders are living longer thanks to better treatments, but some are now developing progressive liver damage and scarring that wasn't visible before. This study aims to identify patterns in how the liver is affected, which could help doctors predict and prevent these complications in future patients.
You likely qualify if…
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If you qualify, you would allow researchers to review and study your existing liver biopsy or transplant records and tissue samples — no new procedures or visits are required. The study team will examine these samples under a microscope to document any scarring, inflammation, or other changes in liver structure and compare patterns across different types of urea cycle disorders.
AI-generated summary from trial data · Jul 2, 2026 · Not medical advice
United States
Sponsor
Baylor College of Medicine
Collaborators
Children's National Research Institute
Enrollment target
~70 participants
Started
February 2022
Primary completion
June 2026
This trial's estimated completion date has passed — the record may not be fully up to date.
Last updated on clinicaltrials.gov in July 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Saima Ali, MSN
Baylor College of Medicine
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.