Plain-English translation of NCT04915183 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
Cisplatin is a powerful chemotherapy drug used to treat head and neck cancer, but it can cause permanent hearing loss as a side effect. This study is testing whether , a common cholesterol-lowering medication, can reduce or prevent this hearing damage when taken alongside cisplatin treatment. Researchers have seen promising results in laboratory studies and patient records, and now they want to confirm whether this medication really works in a larger group of patients.
Hearing loss from cisplatin chemotherapy can be severe and permanent, significantly affecting quality of life. There is currently no proven way to prevent this side effect, so this study is exploring whether this medication might offer patients protection during their cancer treatment.
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If you join this study, you will take either the medication or a placebo (a pill with no active ingredient) by mouth once daily while undergoing your cisplatin chemotherapy and radiation treatment. You will have hearing tests at the start of the study and again about 12 weeks after your chemotherapy ends to see how your hearing has been affected. The study will also track your overall health and survival over a 2-year period following your cancer treatment.
AI-generated summary from trial data · Jun 13, 2026 · Not medical advice
United States