Targeted radiation and medication for breast cancer spread to the brain

This trial is testing whether abemaciclib—a medication that slows cancer cell growth—works better when combined with stereotactic radiation (a focused, high-dose radiation treatment) for people whose hormone-responsive breast cancer has spread to the brain. The study involves taking the medication for one week, then receiving targeted radiation to the brain tumors while continuing the medication. Researchers want to see if this combination is safe and effective at stopping the cancer from growing in the brain.

When breast cancer spreads to the brain, it becomes much harder to treat and can cause serious symptoms or neurological damage. Current standard treatments don't always work well enough, so doctors are exploring whether this medication—which targets the specific type of breast cancer cells—can improve outcomes when paired with precision radiation therapy.