Plain-English translation of NCT04923685 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Major Depressive Disorder research guide →Researchers are looking for biological markers — specific patterns in tiny molecules called microRNAs found in your blood — that may explain the connection between childhood trauma and suicide risk in people with depression. This study involves donating blood samples and completing some stress tests to help scientists understand how past trauma might change your body's cells in ways that affect mental health.
People who experienced childhood abuse and have depression are at higher risk for suicide, but scientists don't fully understand why this happens at the biological level. This research aims to find a "molecular signature" — a specific pattern in your blood — that could one day help doctors identify and better protect people at highest risk.
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You will visit the research center where staff will collect a blood sample and ask you questions about your mental health history and any childhood trauma. You may also be asked to complete a mild stress test (like giving a short speech) while researchers monitor how your body responds and collect additional samples. The study involves different groups — some with depression and trauma history, some with depression alone, some with trauma but no depression, and some healthy volunteers — so your specific visits and number of appointments may vary based on which group you join.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
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