Plain-English translation of NCT04924270 on ClinicalTrials.gov ↗ · Source last updated ·
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This study is testing a treatment called capsule FMT (fecal microbiota transplantation) — capsules containing healthy bacteria from a donor's stool — in people who have just been diagnosed with one of several inflammatory diseases affecting the joints or digestive system. The trial will compare this new treatment to a placebo (a dummy capsule with no active ingredient) to see if it helps reduce symptoms and improve quality of life over one year.
Research suggests that people with these inflammatory diseases have differences in their gut bacteria that may contribute to their condition. This trial explores whether restoring healthy bacteria through this treatment might help calm inflammation and improve symptoms in newly diagnosed patients before they start standard medications.
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You will receive four capsule treatments during your first month (one per week), and you'll also start standard medication for your condition as recommended by your doctor. Over 52 weeks, you'll have clinical check-ups and complete health surveys at weeks 8, 26, and 52 to track how you're doing. Throughout the trial, researchers will monitor you for any side effects and measure improvements in your symptoms using standardized disease-specific assessments.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
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