Plain-English translation of NCT04925414 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Migraine research guide →Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This trial is testing whether high-flow oxygen therapy can help stop migraine attacks when you arrive at the emergency room. Right now, doctors commonly use pain medications to treat migraines, but this study wants to see if oxygen therapy might work just as well — or better — with fewer side effects. You would receive either real oxygen or placebo air through a mask to see if it reduces your migraine pain.
Migraine affects millions of people and sends many to emergency rooms each year. While oxygen therapy is already known to help with cluster headaches, it hasn't been properly tested for regular migraines. This medication could offer patients relief without relying heavily on pain medications, which can have unwanted side effects.
You likely qualify if…
You likely don't qualify if…
You would come to the emergency room during a migraine attack and be enrolled in the study. Half of participants would receive high-flow oxygen therapy through a mask, while the other half would receive placebo air. The study will track how quickly your migraine improves and how long you need to stay in the emergency room. Your participation helps doctors understand whether this simple, safe treatment could become a new option for migraine relief.
AI-generated summary from trial data · Jun 10, 2026 · Not medical advice
France