Plain-English translation of NCT04930887 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether Exparel, a long-acting numbing medication, can help relieve severe facial and head pain when injected through an endoscope (a thin camera) into a specific area near the nasal cavity. The medication is already used successfully in surgery to provide pain relief for up to 72 hours, and researchers want to see if this treatment can help people with migraines, cluster headaches, and other types of severe facial pain.
Many people suffer from severe, hard-to-treat facial and head pain that doesn't respond well to regular treatments. This trial exists because early signs suggest that numbing a specific nerve pathway in the nasal area might provide significant pain relief, and researchers want to test whether this medication can safely and effectively help patients.
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You would visit Stanford's clinic for a procedure in which doctors use a thin camera (endoscope) to guide a small injection of either the test medication or saline (salt water) into an area near your nasal cavity. The procedure itself takes about an hour, and you would be monitored for a short time afterward. Because this is a crossover trial, you may receive both the medication and saline at different visits so researchers can compare how each affects your pain.
AI-generated summary from trial data · Jun 1, 2026 · Not medical advice
United States