Plain-English translation of NCT04937998 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether a single injection of autologous PRP (a concentration of healing factors from your own blood) works better than hyaluronic acid for treating osteoarthritis of the kneecap. You would receive one injection into your knee and then be followed for up to 2 years to see how well the treatment works and whether your pain and function improve.
Kneecap arthritis is common and painful, and current treatments don't work equally well for everyone. Researchers want to know if this medication—which uses your body's own healing components—might offer better or longer-lasting relief than the standard hyaluronic acid injection.
You likely qualify if…
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You would receive one injection into your knee joint at the start of the study. After that, you would return for clinical check-ups and complete questionnaires about your pain and knee function at 2 months, 6 months, 12 months, and 24 months. The study lasts 2 years total, and you would be randomly assigned to receive either the blood-derived injection or the hyaluronic acid injection—neither you nor the study team will know which one you receive until the study ends.
AI-generated summary from trial data · Jun 24, 2026 · Not medical advice
Italy
Sponsor
Istituto Ortopedico Rizzoli
Enrollment target
~166 participants
Started
October 2022
Primary completion
September 2026
Age range
30 Years – 65 Years
Last updated on clinicaltrials.gov in December 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Roberta Licciardi, MSc
Istituto Ortopedico Rizzoli
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.