Plain-English translation of NCT04945213 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing whether , a medication already used for Parkinson's disease, can prevent seizures from developing after a moderate or severe head injury. Researchers believe this medication may help protect the brain and stop epilepsy from starting. You would receive either the medication or a placebo (a dummy treatment with no active drug) through an IV for 10 days, then be followed for two years to see if you develop seizures.
After a severe head injury, many patients develop epilepsy and unpredictable seizures that can be dangerous and life-altering. Currently, there is no proven way to prevent this from happening. This study hopes to find out if this medication can stop epilepsy from developing in the first place, rather than just treating seizures after they've started.
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If you join this study, you would receive either the medication or a placebo through an IV every 6 hours for 10 consecutive days after your injury. After this initial treatment period, you would return for regular follow-up visits over the next two years so doctors can monitor whether you develop any seizures. The study team will track your health and any symptoms during these visits to see if the treatment made a difference.
AI-generated summary from trial data · Jun 19, 2026 · Not medical advice
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