Plain-English translation of NCT04954599 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.
This is an early-stage trial testing a new experimental medication called in people with advanced cancer. The study will test the medication in three different ways: alone, combined with a chemotherapy drug called , and combined with immunotherapy drugs. Researchers are looking for the right dose and checking whether the medication is safe and whether it helps shrink tumors.
Some cancers have specific DNA repair defects that may make them vulnerable to this new treatment. This trial is designed to find out if the medication can help patients whose cancers have these defects or who haven't responded well to standard treatments.
You likely qualify if…
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You will visit the clinic regularly for blood tests, scans, and biopsies to check how you and the medication are doing. Depending on which module you join, you may take the medication alone, or it may be combined with chemotherapy or immunotherapy. The study has a dose-finding phase where doses are gradually increased to find the safest and most effective level, followed by an expansion phase where more patients receive the recommended dose.
AI-generated summary from trial data · Jun 18, 2026 · Not medical advice
Belgium
Netherlands
Spain