Plain-English translation of NCT04957901 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Lymphoma research guide →Researchers are studying whether a simple blood test that detects circulating tumor DNA (cancer DNA floating in the bloodstream) can help doctors better understand how children's lymphomas respond to chemotherapy. By collecting blood samples before, during, and after treatment, the study aims to learn whether this test can predict which children will respond well to treatment, which ones might relapse, and why some cancers become resistant to chemotherapy.
Currently, doctors rely on imaging scans and clinical exams to check if lymphoma treatment is working, but these methods can miss early warning signs of treatment failure. This study exists to see whether a blood test could give doctors earlier and more precise information about whether treatment is working, potentially allowing them to adjust care sooner if needed.
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You would have blood samples (and possibly bone marrow or spinal fluid samples) taken before you start chemotherapy, at regular intervals during your treatment, and after treatment ends. These samples would be analyzed to detect and track cancer DNA. You would continue your regular lymphoma treatment as prescribed by your oncologist—this study is observational, meaning it watches and measures rather than changing your treatment plan. The study involves about 60 children across multiple hospitals.
AI-generated summary from trial data · Jun 12, 2026 · Not medical advice
China
Sponsor
Sun Yat-sen University
Enrollment target
~60 participants
Started
December 2021
Primary completion
June 2026
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
1 Year – 18 Years
Last updated on clinicaltrials.gov in June 2025.
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Central contact
Yizhuo Zhang
Sun Yat-sen University CancerCenter
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