Plain-English translation of NCT04958122 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing whether cefixime, an oral antibiotic taken as pills, works just as well as G (a penicillin injection) for treating early syphilis. You would receive one of these two treatments and then have follow-up visits over 9 months to see how well it worked. This research includes people both with and without HIV infection.
There is a shortage of penicillin available right now, and some people are allergic to penicillin. This trial aims to find an effective pill-based treatment option so that people with syphilis have more choices and can still get the care they need.
You likely qualify if…
You likely don't qualify if…
You will be randomly assigned to receive either the oral medication (a pill taken twice daily for 10 days) or a single injection. After that, you'll come back to the clinic every 3 months for 9 months to have blood tests and check on how you're responding to the treatment. The study team will monitor you to make sure the medication is working and to watch for any side effects.
AI-generated summary from trial data · Aug 7, 2026 · Not medical advice
United States
Phase
Large-scale testing
Sponsor
University of Southern California
Collaborators
AIDS Healthcare Foundation, Universidad Peruana Cayetano Heredia
Enrollment target
~400 participants
Started
June 2021
Primary completion
January 2027
Age range
18 Years and older
Last updated on clinicaltrials.gov in May 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Jeffrey D Klausner
University of Southern California
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.