Plain-English translation of NCT04968990 on ClinicalTrials.gov ↗ ·
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing proton beam radiation therapy (PBRT) for children with newly diagnosed Wilms tumor, a type of kidney cancer. Proton beam radiation is a more precise form of radiation that aims to target the tumor while sparing healthy tissues around it. Depending on the stage of your child's cancer and what doctors find during surgery, they may receive this specialized radiation along with standard chemotherapy.
Traditional radiation therapy can damage healthy organs near the tumor, especially in growing children. Proton beam radiation is designed to be more targeted and potentially cause fewer long-term side effects, while still treating the cancer effectively.
You likely qualify if…
You likely don't qualify if…
If your child qualifies, they will first receive chemotherapy (cancer drugs) for 6–12 weeks to shrink the tumor, followed by surgery to remove the kidney or tumor. Depending on what doctors find during surgery and the stage of cancer, your child may then receive proton beam radiation to the abdomen. Throughout the trial, your child will be followed with regular check-ups, imaging scans, and blood tests as part of standard cancer care. The trial aims to enroll about 260 children at hospitals across multiple centers.
AI-generated summary from trial data · Jun 7, 2026 · Not medical advice
United States