Plain-English translation of NCT04973423 on ClinicalTrials.gov ↗ ·
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether adding regular MRI scans to standard blood tests helps doctors treat Crohn's disease better in patients starting biotherapy. The study compares two groups: one that uses only blood tests to monitor inflammation, and another that combines blood tests with MRI scans to get a more complete picture of intestinal inflammation. The goal is to see if MRI scans help catch inflammation earlier and improve long-term outcomes.
Doctors currently rely mainly on blood tests and symptoms to decide when to adjust Crohn's disease treatment, but sometimes inflammation is hiding deep in the intestinal walls where blood tests can't detect it. This trial is testing whether adding MRI scans—which can see the full thickness of the bowel—helps doctors catch and treat this hidden inflammation sooner, potentially preventing complications and improving healing.
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You will be randomly assigned to one of two groups and followed for about 3 years (152 weeks). Both groups will have regular blood tests to measure inflammation and keep a symptom diary. The first group receives standard care with check-ins at 8 time points. The second group receives the same blood testing plus additional MRI scans at weeks 24 and 52 to detect hidden inflammation, with treatment adjustments made based on those scans. All participants will have MRI scans at the beginning and end of the study.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
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