Plain-English translation of NCT04982419 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
The RICH Trial is testing a simple procedure called remote ischemic preconditioning—where a blood pressure cuff is inflated on your arm in a specific pattern—to see if it can protect your kidneys and heart during a coronary angiography or intervention procedure. This treatment uses the cuff to briefly restrict and then restore blood flow to your arm, which may prepare your body to better handle stress during your heart procedure. Researchers want to know if this approach can prevent kidney injury and improve heart function in people with heart failure.
People with weakened hearts who undergo heart procedures are at higher risk of kidney injury from the contrast dye used during the procedure. This trial exists to find a simple, non-invasive way to protect both the heart and kidneys during these procedures and improve outcomes for heart failure patients.
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If you join this trial, you will be randomly assigned to receive either the active treatment or a sham (placebo) version. Before your scheduled heart procedure, a blood pressure cuff will be applied to your arm and inflated in a specific pattern—either to full pressure or very light pressure, depending on which group you're in. The cuff cycles on and off for about 30 minutes total. Afterward, you'll have blood tests at set intervals and follow-up visits at one month and three months to track your heart and kidney function, and to see if the treatment made a difference in your recovery.
AI-generated summary from trial data · Jun 25, 2026 · Not medical advice
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