Plain-English translation of NCT04984473 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers at Mayo Clinic are studying whether breathing muscle training—exercises that strengthen the muscles you use to breathe—can help improve heart function when combined with a standard cardiac rehabilitation program. The study will compare two groups: one doing very light breathing exercises and one doing more intensive breathing exercises, both over 12 weeks. They want to see if stronger breathing muscles help the heart work better during exercise.
People with heart failure often have difficulty exercising and may experience problems with blood flow and blood pressure during physical activity. This trial is exploring whether training the breathing muscles could be a simple, additional tool to help improve these exercise responses and overall heart function.
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You would attend a center-based cardiac rehabilitation program for 12 weeks and perform breathing muscle training exercises during your visits. Depending on which group you are randomly assigned to, you will do either very light breathing exercises (at 2% intensity) or more challenging breathing exercises (at 40% intensity). The researchers will measure your blood flow and blood pressure response during exercise at the beginning and end of the study.
AI-generated summary from trial data · Jul 20, 2026 · Not medical advice
United States
Sponsor
Mayo Clinic
Enrollment target
~42 participants
Started
June 2021
Primary completion
August 2027
Age range
18 Years and older
Last updated on clinicaltrials.gov in July 2026.
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Central contact
Eric Bruhn, MA
Mayo Clinic
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.