Plain-English translation of NCT04984512 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Depressive Disorder, Major research guide →Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing a new medication called Mitizodone Phosphate to see if it can help people with major depression feel better. The study will first figure out which dose works best and causes the fewest side effects, then confirm those results in a larger group of patients. Researchers will compare the medication to a placebo (a pill with no active ingredient) to see how well it really works.
Major depression is a serious condition that affects millions of people, and many patients don't respond well enough to medications that are currently available. This trial aims to find out whether this new treatment could be a safe and effective option for people struggling with depression.
You likely qualify if…
You likely don't qualify if…
If you join this study, you will take a tablet by mouth once daily for about 10 weeks. Depending on which group you're randomly assigned to, you might receive the medication at different doses or a placebo. The study includes an 8-week main treatment phase followed by a 2-week follow-up period. You will visit the clinic multiple times for check-ins so researchers can monitor how you're responding and watch for any side effects.
AI-generated summary from trial data · Jun 11, 2026 · Not medical advice
China