Plain-English translation of NCT04987879 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether exercise can help treat fatty liver disease (a condition where fat builds up in your liver) by activating a natural process in your body called AMPK that helps break down fat. Researchers aren't sure exactly how much exercise is needed to activate this process, so this study will compare two different exercise doses to find out what works best.
We know exercise helps people with fatty liver disease, but doctors don't understand exactly how it works or how much exercise is needed. This trial will help answer those questions so we can give patients better guidance on exercise for treating this condition.
You likely qualify if…
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You will be randomly assigned to one of three groups: a lower-dose exercise program (about 750 calories burned per week through cardio), a higher-dose exercise program (about 1,000 calories burned per week), or a control group that receives standard care counseling. If you're in an exercise group, you'll do aerobic activities like walking, jogging, or using a stationary bike for 3–5 days per week over several weeks, either at a gym or virtually from home. You'll have visits at the start and end of the study to check your progress.
AI-generated summary from trial data · Jun 9, 2026 · Not medical advice
United States
Sponsor
Milton S. Hershey Medical Center
Enrollment target
~45 participants
Started
August 2022
Primary completion
May 2026
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years – 69 Years
Last updated on clinicaltrials.gov in October 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Breianna L Hummer, MS
Milton S. Hershey Medical Center
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.