Plain-English translation of NCT04990609 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a combination of two treatments given before surgery for pancreatic cancer: standard chemotherapy plus a newer procedure called endoscopic ultrasound radiofrequency ablation (EUS-RFA), which uses heat delivered through an endoscope to target the tumor. The goal is to shrink the cancer or stop it from spreading so that surgery can be less invasive and more effective.
Pancreatic cancer is difficult to treat and surgery outcomes are often limited. Researchers want to see if this heat-based treatment combined with chemotherapy can better prepare tumors for surgery and improve results for patients.
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You would receive rounds of standard chemotherapy combined with multiple sessions of the heat treatment procedure before your cancer surgery. The heat treatment is delivered through an endoscope (a thin tube passed down your throat), so you would be sedated during those procedures. The entire treatment plan would take place over several weeks leading up to your surgery, with regular clinic visits for monitoring and assessments.
AI-generated summary from trial data · Jul 18, 2026 · Not medical advice
United States