Plain-English translation of NCT04990609 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether giving chemotherapy together with a newer procedure called endoscopic ultrasound radiofrequency ablation (EUS-RFA) can help treat pancreatic cancer more effectively. The idea is to use this combination treatment before surgery to shrink the tumor or slow its growth, which might make surgery less invasive and more successful. Doctors hope that preparing the cancer this way will give patients better outcomes.
Pancreatic cancer is very hard to treat, and surgery alone often doesn't cure it. Researchers want to see if combining standard chemotherapy with this newer heat-based procedure can shrink tumors enough to make surgery work better and give patients a better chance of survival.
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You would receive chemotherapy (the standard first-line treatment for pancreatic cancer) combined with multiple rounds of a procedure called endoscopic ultrasound radiofrequency ablation, which uses heat delivered through an endoscope to target and destroy cancer cells. Both treatments would happen before you have surgery to remove the tumor, with the goal of making the cancer smaller or easier to treat surgically. The study will monitor your safety and how well the combination works, with about 60 patients enrolling in total.
AI-generated summary from trial data · Aug 16, 2026 · Not medical advice
United States