Plain-English translation of NCT04992195 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Stroke research guide →Researchers want to understand how COVID-19 vaccines (specifically SinoVac or BioNTech) affect the brain's blood vessels and thinking abilities. This study will compare people who received the vaccine to people who did not, using brain imaging scans and memory tests to see if there are any changes in brain health over time.
There are concerns and questions about how vaccines might affect the brain and blood vessels. This research aims to provide clear evidence about whether the medication impacts cerebrovascular health—the health of blood vessels in the brain—and whether it affects memory or thinking skills.
If you join the vaccination group, you will receive your COVID-19 vaccine (as planned), then return for a second brain MRI scan about 16 weeks after your second vaccine dose. You'll also have memory tests, blood work, and check-ins with the research team at baseline and follow-up visits. If you're in the control group (no vaccine), you'll complete the same baseline tests and occasional follow-up visits for comparison. The study includes in-person visits and phone check-ins every 6 months for at least one year.
AI-generated summary from trial data · Jun 4, 2026 · Not medical advice
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