Plain-English translation of NCT04996433 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial tests two different talk therapy approaches for people with persistent depression that hasn't improved with other treatments. You would receive either Cognitive Behavioral Analysis System of Psychotherapy (CBASP), a therapy specifically designed for long-term depression, or Behavioral Activation (BA), a well-established therapy that focuses on helping you re-engage with activities. Both treatments are combined with standard depression medications and last about 4 months total.
About half of people hospitalized for depression have a long-lasting form that is very hard to treat. Researchers want to know if the new treatment works better than the gold-standard approach, and they want to understand which patients benefit most from each type of therapy.
You likely qualify if…
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You would stay in the hospital or day clinic for 10 weeks while receiving either CBASP or BA therapy sessions combined with your regular depression medications. After that, you would attend 6 weeks of outpatient group therapy sessions. Throughout the program, your depression symptoms and response to treatment would be measured regularly to see which approach works best for you.
AI-generated summary from trial data · Jun 20, 2026 · Not medical advice
Germany