Plain-English translation of NCT04997642 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Parkinson Disease research guide →This research study is building a comprehensive database of information from people with Parkinson's disease and related conditions. Researchers will collect your medical history, family background, brain imaging, and biological samples (like blood) to study how the disease develops, progresses, and responds to treatment.
Parkinson's disease affects people differently, and doctors don't yet fully understand why some people develop dementia or other complications while others don't. This database will help researchers identify patterns, genetic factors, and early warning signs so they can improve how the disease is diagnosed and managed.
You likely qualify if…
You likely don't qualify if…
You'll visit the clinic once a year for the first four years, then every two years after that. During visits, you'll share your medical history, complete neurological exams, answer questions about your symptoms, have blood or tissue samples taken, and potentially undergo brain imaging. The study continues as long as you're able and willing to participate.
AI-generated summary from trial data · Jun 28, 2026 · Not medical advice
United States
Sponsor
University of Pennsylvania
Collaborators
National Institute on Aging (NIA)
Enrollment target
~250 participants
Started
September 2019
Primary completion
September 2029
Age range
18 Years and older
Last updated on clinicaltrials.gov in October 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Eugenia Mamikonyan
University of Pennsylvania
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.